Tackling Alzheimer’s Disease with Existing Drugs: A Promising Strategy for Bypassing Obstacles

The unmet need for the development of effective drugs to treat Alzheimer's disease has been steadily growing, representing a major challenge in drug discovery. In this context, repurposing, namely identification novel therapeutic indications approved or investigational compounds, can be seen as an attractive attempt obtain new medications reducing both time and economic burden usually required research programs. last years, several classes have evidenced promising beneficial effects neurodegenerative diseases, some them, preliminary clinical trials started. This review aims illustrate most recent examples reprofiled Alzheimer’s disease, considering not only finding uses existing but also hypotheses on pathogenesis that could promote previously unconsidered regimens. Moreover, structural modifications performed order multifunctional compounds will described.